Multifocal breast cancer

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Bilateral and Multifocal Breast Cancer.

Widespread mammography and the increasing use of breast-conserving therapy make bilateral and multifocal breast cancer more important issues in patient care. The biologic mechanisms of these two cancer types differ. Bilateral breast cancer results from independent primaries in the two breasts, while multifocal breast cancer can result from either intramammary spread from a single index tumor or...

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Oncoplastic Surgery of Multicentric (Multifocal) Breast Cancer

The breast-conserving treatment, in essence, implies not only providing breast-conserving surgery (BCS), but also adjuvant radiation therapy, that significantly reduces the risk of disease loco-regional and distant recurrence and is considered as an integral part of breast cancer conservative treatment [1,2]. Traditionally, appearance of more than one malignant tumor, in one or several breast q...

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multifocal/multicentric versus unifocal breast cancer: what is the difference?

background: although multifocal and multicentric breast cancers are a common entity, their clinical behavior is not well characterized. with the widespread use of mammographic screening and improved sensitivity of imaging modalities, the detection of multifocal and multicentric breast cancers is likely to continuously increase. many studies have consistently shown a correlation between multifoc...

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Tumor size and survival in multicentric and multifocal breast cancer.

PURPOSE Current AJCC/UICC staging of early breast cancer defines tumor stage using the largest focus, adding the suffix "(m)" to indicate multiplicity. This method may underestimate the total tumor burden in multifocal and multicentric breast cancer (MMBC). This study examines other measures of tumor size in MMBC to determine which provides the best fit in a multivariate model for survival outc...

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Uncovering the genomic heterogeneity of multifocal breast cancer

Multifocal breast cancer (MFBC), defined as multiple synchronous unilateral lesions of invasive breast cancer, is relatively frequent and has been associated with more aggressive features than unifocal cancer. Here, we aimed to investigate the genomic heterogeneity between MFBC lesions sharing similar histopathological parameters. Characterization of different lesions from 36 patients with duct...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 2000

ISSN: 0032-5473

DOI: 10.1136/pmj.76.899.554